Asymmetric synthesis of bicyclic pyran scaffolds bearing two oxa-quaternary stereocenters <i>via</i> zinc-catalyzed [5 + 1] annulations
Cui Zhang, Tao Jiang, Yuan‐Zhao Hua, Guang‐Jian Mei, Min‐Can Wang, Shi‐Kun Jia
Abstract
Zinc-catalyzed [5 + 1] annulation of α-hydroxyl aryl ketones with cyclohexadienone-tethered enones has been developed, giving access to enantioenriched bicyclic pyran scaffolds bearing two oxa-quaternary stereocenters.
Topics & Concepts
StereocenterChemistryPyranBicyclic moleculeAnnulationCatalysisZincArylStereochemistryEnantioselective synthesisCombinatorial chemistryMedicinal chemistryOrganic chemistryAlkylSynthetic Organic Chemistry MethodsAsymmetric Synthesis and CatalysisOxidative Organic Chemistry Reactions