Beyond direct Nrf2 activation; reinvestigating 1,2,4-oxadiazole scaffold as a master key unlocking the antioxidant cellular machinery for cancer therapy
Mohammed Salah Ayoup, Marwa M. Abu‐Serie, Hamida Abdel‐Hamid, Mohamed Teleb
Topics & Concepts
ChemistryAntioxidantOxidative stressNADPH oxidaseOxadiazoleReactive oxygen speciesIC50Cancer cellKEAP1BiochemistryPharmacologyCancerIn vitroTranscription factorMedicineGeneOrganic chemistryInternal medicineGenomics, phytochemicals, and oxidative stressRedox biology and oxidative stressGlutathione Transferases and Polymorphisms