Boosting Replication and Penetration of Oncolytic Adenovirus by Paclitaxel Eradicate Peritoneal Metastasis of Gastric Cancer
Wataru Ishikawa, Satoru Kikuchi, Toshihiro Ogawa, Motoyasu Tabuchi, Hiroshi Tazawa, Shinji Kuroda, Kazuhiro Noma, Masahiko Nishizaki, Shunsuke Kagawa, Yasuo Urata, Toshiyoshi Fujiwara
Abstract
imaging system demonstrated that the combination therapy of i.p. OBP-401 administration with PTX significantly inhibited growth of peritoneal metastatic tumors and the amount of malignant ascites. i.p. virotherapy with PTX may be a promising treatment strategy for the peritoneal metastasis of gastric cancer.
Topics & Concepts
Oncolytic virusOncolytic adenovirusMetastasisMedicineCancer researchPaclitaxelCancer cellCancerSystemic administrationPeritoneal cavityCombination therapyIn vivoInternal medicineBiologySurgeryBiotechnologyVirus-based gene therapy researchCancer Research and TreatmentsOvarian cancer diagnosis and treatment