Heterogeneity of intrinsic plasticity in cerebellar Purkinje cells linked with cortical molecular zones
Viet T. Nguyen‐Minh, Tianzhuo Wang, Khoa Tran-Anh, Izumi Sugihara
Abstract
whole-cell patch-clamp recording in Z+ and Z- PCs in vermal and hemispheric neighboring zebrin zones in zebrin-visualized mice. Intrinsic excitability is significantly higher in Z- PCs than in Z+ PCs. Furthermore, intrinsic plasticity and synaptic long-term potentiation are enhanced more in Z- PCs than in Z+ PCs. The difference was mediated by different modulation of SK channel activities between Z+ and Z- PCs. The results indicate that cellular physiology differentially tunes to the functional compartmentalization of heterogeneous PCs.
Topics & Concepts
NeuroscienceCerebellar cortexPurkinje cellLong-term potentiationCompartmentalization (fire protection)PlasticityNeuroplasticityBiologyChemistryCerebellumPhysicsReceptorBiochemistryEnzymeThermodynamicsNeuroscience and Neuropharmacology ResearchVestibular and auditory disordersNeural dynamics and brain function