Anticancer potential of some imidazole and fused imidazole derivatives: exploring the mechanism <i>via</i> epidermal growth factor receptor (EGFR) inhibition
Sourav Kalra, Gaurav Joshi, Manvendra Kumar, Sahil Arora, Harsimrat Kaur, Sandeep Singh, Anjana Munshi, Raj Kumar
Abstract
Imidazole-based epidermal growth factor receptor (EGFR) inhibitors were computationally designed and synthesized.
Topics & Concepts
ImidazoleEpidermal growth factor receptorMechanism (biology)ChemistryEpidermal growth factorPharmacologyCancer researchReceptorBiochemistryBiologyPhilosophyEpistemologySynthesis and biological activitySynthesis of Tetrazole DerivativesComputational Drug Discovery Methods