The A137R Protein of African Swine Fever Virus Inhibits Type I Interferon Production via the Autophagy-Mediated Lysosomal Degradation of TBK1
Maowen Sun, Shaoxiong Yu, Hailiang Ge, Tao Wang, Yongfeng Li, Pingping Zhou, Li Pan, Yu Han, Yuying Yang, Yuan Sun, Su Li, Lian‐Feng Li, Hua‐Ji Qiu
Abstract
gene-deleted ASFV mutant promoted the expression of type I interferon (IFN) in primary porcine alveolar macrophages. Further analysis indicated that the A137R protein negatively regulated the cGAS-STING-mediated IFN-β signaling pathway through targeting TANK-binding kinase 1 (TBK1) for autophagy-mediated lysosomal degradation. This study not only facilitates the understanding of ASFV immunoevasion strategies, but also provides new clues to the development of live attenuated ASF vaccines.
Topics & Concepts
African swine fever virusBiologyVirulenceVirologyTANK-binding kinase 1InterferonVirusGeneAutophagyMicrobiologyGeneticsApoptosisCyclin-dependent kinase 2Cell cycleAnimal Disease Management and EpidemiologyViral Infections and VectorsVector-Borne Animal Diseases