<i>In Vitro</i> Antibacterial Activity and <i>In Vivo</i> Efficacy of Sulbactam-Durlobactam against Pathogenic <i>Burkholderia</i> Species
Krisztina M. Papp‐Wallace, Adam B. Shapiro, Scott A. Becka, Elise T. Zeiser, John J. LiPuma, Douglas Lane, Rekha G. Panchal, John P. Mueller, John P. O’Donnell, Alita A. Miller
Abstract
The Gram-negative bacterial genus Burkholderia includes several hard-to-treat human pathogens: two biothreat species, Burkholderia mallei (causing glanders) and B. pseudomallei (causing melioidosis), and the B. cepacia complex (BCC) and B. gladioli , which cause chronic lung infections in persons with cystic fibrosis. All Burkholderia spp. possess an Ambler class A Pen β-lactamase, which confers resistance to β-lactams.
Topics & Concepts
BurkholderiaMelioidosisMicrobiologyBurkholderia cepacia complexBurkholderia pseudomalleiBiologySulbactamIn vivoIn vitroBacteriaVirologyAntibiotic resistanceAntibioticsImipenemGeneticsBiotechnologyBiochemistryBurkholderia infections and melioidosisAntibiotic Resistance in Bacteria