Structural basis for DCAF2 as a novel E3 ligase for PROTAC-mediated targeted protein degradation
Evan McMahon, Alexander G. Cioffi, Patrick R. Visperas, Yueqing Lin, Michael B. Shaghafi, Courtney M. Daczkowski, Johannes C. Hermann, Robert A. Everley, Richard M. Neve, Daniel A. Erlanson, Kevin R. Webster, Vikram M. Narayan, Weiru Wang
Topics & Concepts
Ubiquitin ligaseTernary complexUbiquitin-Protein LigasesUbiquitinDNA ligaseSignal transducing adaptor proteinDDB1ChemistryProtein degradationBiochemistryPlasma protein bindingProtein structureProtein–protein interactionCell biologyTarget proteinDNABiophysicsCovalent bondBifunctionalF-box proteinBinding siteProtein foldingLigand (biochemistry)Zinc fingerDNA origamiDNA-binding proteinStructural biologyResidue (chemistry)Protein engineeringProteasomeEndoplasmic-reticulum-associated protein degradationBiologyProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysPeptidase Inhibition and Analysis