17β-Estradiol promotes sex-specific dysfunction in isolated human arterioles
Gopika SenthilKumar, Boran Katunaric, Henry Bordas-Murphy, Micaela Young, Erin L. Doren, Mary E. Schulz, Michael E. Widlansky, Julie K. Freed
Abstract
Microvascular dysfunction is an independent predictor of adverse cardiac events; however, the effect of estrogen on the human microcirculation represents a critical knowledge gap. To our knowledge, this is the first study to report sex-specific detrimental effects of chronic estrogen on human microvascular reactivity. These findings may offer insight into the increased CVD risk associated with estrogen use in both cis- and trans-females.
Topics & Concepts
EstrogenMicrocirculationCardiac dysfunctionMedicineInternal medicineEstrogen receptorHuman studiesEndocrinologyPhysiologyBiologyHeart failureBreast cancerCancerMenopause: Health Impacts and TreatmentsEstrogen and related hormone effectsSex and Gender in Healthcare