Sensitivity, specificity and limitation of in vitro hippocampal slice and neuron-based assays for assessment of drug-induced seizure liability
Jin Zhai, Yingying Zhou, Armando Lagrutta
Topics & Concepts
NeuroscienceGlutamate receptorHippocampal formationMetabotropic glutamate receptorPharmacologyMetabotropic receptorIn vitroDrug discoveryPopulationHippocampusDrugBiologyReceptorChemistryMedicineBioinformaticsBiochemistryEnvironmental healthNeuroscience and Neuropharmacology ResearchNeuroscience and Neural EngineeringEpilepsy research and treatment