Achromobacter xylosoxidans Cellular Pathology Is Correlated with Activation of a Type III Secretion System
Adam M. Pickrum, Orlando DeLeon, Aaron Dirck, Maxx H. Tessmer, Molly O. Riegert, Julie Biller, Nathan A. Ledeboer, John R. Kirby, Dara W. Frank
Abstract
Achromobacter xylosoxidans is increasingly recognized as a colonizer of cystic fibrosis (CF) patients, but the role that A. xylosoxidans plays in pathology remains unknown. This knowledge gap is largely due to the lack of model systems available to study the toxic potential of this bacterium. Recently, a phospholipase A 2 (PLA 2 ) encoded by a majority of A. xylosoxidans genomes, termed AxoU, was identified.
Topics & Concepts
Achromobacter xylosoxidansBiologyCystic fibrosisMicrobiologySecretionAchromobacterBacteriaGeneticsBiochemistryPseudomonasInfections and bacterial resistancePlant Pathogenic Bacteria StudiesBacterial biofilms and quorum sensing