Bifunctional Phosphonium Salt‐catalyzed Enantioselective [4+2] Annulation of Isoindigos with Allenes: Access to Complex Heterocycles with Centerpiece of 4<i>H</i>‐Pyrans
Juan Du, Jia‐Hong Wu, Lixiang Zhu, Xiaoyu Ren, Chunhui Jiang, Tianli Wang
Abstract
Abstract Structurally fused heterocycles encompassing 4 H ‐pyran centerpiece are prevalent scaffolds with promising biological activities, but have daunting synthetic challenges. Herein, we presented a regio‐ and stereoselective [4+2] annulation of isoindigo derivatives with allenes by bifunctional phosphonium catalysis. This protocol provides a complementary way for accessing complex heterocyclic compounds. magnified image
Topics & Concepts
ChemistryBifunctionalAnnulationEnantioselective synthesisPhosphonium saltPhosphoniumCatalysisPyranCombinatorial chemistryOrganocatalysisStereoselectivitySalt (chemistry)Organic chemistryStereochemistryCatalytic C–H Functionalization MethodsOxidative Organic Chemistry ReactionsSynthetic Organic Chemistry Methods