Synthesis and Anticancer Activity of New Pyridine-Thiophene andPyridine-Furan Hybrid Compounds, Their Sugar Hydrazone, and GlycosylDerivatives
Hemat S. Khalaf, Hala E. M. Tolan, Mohamed N. El‐Bayaa, Mohamed A. A. Radwan, May A. El‐Manawaty, Wael A. El‐Sayed
Abstract
Abstract New sugar hydrazones and their derived oxadiazolyl acyclic nucleoside analogs in addition to the derived thioglycosides incorporating pyridine, furan or thiophene have been synthesized via a multi-component reaction (MCR). The acetylated derivatives of hydrazones and the derived deprotected thioglycosides of the prepared acetylated analogs have been also synthesized. Anticancer activity of the products has been tested against adenocarcinomic human alveolar basal epithelial (A549), human prostatic adenocarcinoma (PC3) and human colorectal carcinoma (HCT116) cell lines in addition to their effect on human normal retinal pigmented epithelial cell line (RPE1) using the MTT assay. Three products: acid hydrazide, sugar hydrazine and glycoside are characterized by high activity against three cancer cell lines.