Circular RNA RRM2 alleviates metabolic dysfunction-associated steatotic liver disease by targeting miR-142-5p to increase NRG1 expression
Long-Fei Wu, Zhijiang Zhou, Yu-Heng Zeng, Shengli Yang, Qingying Zhang
Abstract
CircRRM2 expression was downregulated in free fatty acid (FFA)-challenged hepatocytes and high-fat diet (HFD) fed mice. Overexpressed circular RNA ribonucleotide reductase subunit M2 (circRRM2) attenuated metabolic dysfunction-associated steatotic liver disease (MASLD) development by suppressing FFA-induced triglycerides accumulation. CircRRM2 targeted microRNA-142-5p (miR-142-5p), which served as an upstream inhibitor of neuregulin 1 (NRG1) and collaboratively regulated MASLD progression.
Topics & Concepts
Circular RNAmicroRNADiseaseRNAMedicineBiologyInternal medicineCancer researchGeneticsGeneCircular RNAs in diseasesMicroRNA in disease regulationCancer-related molecular mechanisms research