Metabolism of insecticide diazinon by <i>Cunninghamella elegans</i> ATCC36112
Mei‐Ai Zhao, Hao Gu, Chuan-Jie Zhang, In-Hong Jeong, Jeong‐Han Kim, Yong-Zhe Zhu
Abstract
were measured. Results indirectly demonstrated that cytochrome P450 and flavin monooxygenase were involved in the metabolism of diazinon, but methimazole inhibited the metabolism less effectively. Based on the metabolic profiling, a possible metabolic pathway involved in phase I metabolism of diazinon was proposed, which would contribute to providing insight into understanding the toxicological effects of diazinon and the potential application of fungi on organophosphorus pesticides.
Topics & Concepts
DiazinonPiperonyl butoxideMetabolismChemistryHydroxylationMonooxygenaseBiochemistryCytochrome P450Detoxification (alternative medicine)MetabolitePesticideEnzymeBiologyToxicityOrganic chemistryAlternative medicineMedicinePathologyAgronomyPesticide and Herbicide Environmental StudiesEnvironmental Toxicology and EcotoxicologyPharmaceutical and Antibiotic Environmental Impacts