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Improving the Cβ stereoselectivity of L-threonine aldolase for the preparation of L-threo-3,4-dihydroxyphenylserine, a powerful anti-Parkinson's disease drug

Renfen Zha, Bijing Lei, Jinsong Ma, Zhi Zhang, Yinping Pan, Bochu Wang, Na Qi

2022Biochemical Engineering Journal11 citationsDOI

Topics & Concepts

Saturated mutagenesisChemistryStereochemistryAldolase AStereoselectivityMutagenesisActive siteSite-directed mutagenesisThreonineEnzymeBiochemistryMutantSerineCatalysisGeneAmino Acid Enzymes and MetabolismPolyamine Metabolism and ApplicationsEnzyme Catalysis and Immobilization
Improving the Cβ stereoselectivity of L-threonine aldolase for the preparation of L-threo-3,4-dihydroxyphenylserine, a powerful anti-Parkinson's disease drug | Litcius