ABCG2 expression and uric acid metabolism of the intestine in hyperuricemia model rat
Chikayuki Morimoto, Yoshifuru Tamura, Shinichiro Asakawa, Emiko Kuribayashi‐Okuma, Yoshikazu Nemoto, Jinping Li, Takayo Murase, Takashi Nakamura, Makoto Hosoyamada, Shunya Uchida, Shigeru Shibata
Abstract
To elucidate roles of the intestine in uric acid (UA) metabolism, we examined ABCG2 expression, tissue UA content and xanthine oxidoreductase (XOR) activity in different intestinal segments. Male SD rats were assigned to control group or oxonic acid-induced hyperuricemia (HUA) group. In control rats, ABCG2 was present both in villi and crypts in each segment. Tissue UA content and XOR activity were relatively high in duodenum and jejunum. However, in HUA rats, tissue UA content was significantly elevated in the ileum, whereas it remained unaltered in other segments. Moreover, ABCG2 expression in the HUA group was upregulated both in the villi and crypts of the ileum. These data indicate that the ileum may play an important role in the extra-renal UA excretion.