Macrophage-Derived Exosomal Mir-155 Regulating Cardiomyocyte Pyroptosis and Hypertrophy in Uremic Cardiomyopathy
Bin Wang, Ze‐Mu Wang, Jialing Ji, Weihua Gan, Aiqing Zhang, Haojie Shi, Hao Wang, Lin‐Li Lv, Zuo‐Lin Li, Tao‐Tao Tang, Jie Du, Xiaonan H. Wang, Bi‐Cheng Liu
Abstract
miR-155 was synthesized and loaded into exosomes in increased infiltration of macrophages in a uremic heart. The released exosomal fusion with the plasma membrane leads to the release of miR-155 into the cytosol and translational repression of forkhead transcription factors of the O class (FoxO3a) in cardiomyocytes. Finally, macrophage-derived miR-155-containing exosomes promoted cardiomyocyte pyroptosis and uremic cardiomyopathy changes (cardiac hypertrophy and fibrosis) by directly targeting FoxO3a in uremic mice.
Topics & Concepts
PyroptosisMicrovesiclesFibrosisAutophagyCell biologyCardiomyopathyTranscription factorCardiac fibrosisMuscle hypertrophyInternal medicineCancer researchMedicineChemistryHeart failureBiologyInflammationmicroRNAInflammasomeApoptosisGeneBiochemistryExtracellular vesicles in diseaseCardiovascular Effects of ExerciseInflammasome and immune disorders