Design, synthesis, and SAR studies of novel 4-methoxyphenyl pyrazole and pyrimidine derivatives as potential dual tyrosine kinase inhibitors targeting both EGFR and VEGFR-2
Abeer M. El‐Naggar, A.M.A. Hassan, Eslam B. Elkaeed, Mohamed S. Alesawy, Ahmed A. Al‐Karmalawy
Topics & Concepts
ChemistryPyrimidineErlotinibPyrazoleEGFR inhibitorsSorafenibDocking (animal)IC50PharmacologyCombinatorial chemistryStereochemistryIn vitroBiochemistryEpidermal growth factor receptorCancer researchReceptorNursingMedicineBiologyHepatocellular carcinomaSynthesis and biological activityHER2/EGFR in Cancer ResearchCytokine Signaling Pathways and Interactions