Lipid nanoparticles produce chimeric antigen receptor T cells with interleukin-6 knockdown in vivo
Jinge Zhou, Lei Sun, Yujie Jia, Zhehao Wang, Tengshuo Luo, Jingwen Tan, Xiaoyan Fang, Hongjia Zhu, Jing Wang, Lei Yu, Zhiqiang Yan
Topics & Concepts
Chimeric antigen receptorEx vivoGene knockdownIn vivoTransfectionCD19Molecular biologyLeukemiaCancer researchInterleukin 12Interleukin 2AntigenCytokineBiologyChemistryT cellImmunologyCytotoxic T cellCell cultureIn vitroApoptosisImmune systemBiochemistryBiotechnologyGeneticsCAR-T cell therapy researchNanowire Synthesis and ApplicationsVirus-based gene therapy research