Three-Component Reaction between 3-Acetylcoumarins, Amines, and Elemental Sulfur: A Designed Approach to 3-Amino-4<i>H</i>-thieno[3,2-<i>c</i>]coumarins
Behnaz Farajpour, Roujin Heydarzadeh, Faiq H. S. Hussain, Behrouz Notash, Peiman Mirzaei, Morteza Shiri
Abstract
In this work, a series of novel 3-amino-4 H -thieno[3,2- c ]coumarins were designed and synthesized by a one-pot, catalyst-free, and three-component reaction of 3-acetylcoumarins with amines and elemental sulfur. Readily available starting materials, simple heating conditions, facile installation of a sulfur atom into the molecule using S 8 as a sulfur source, acceptable functional group tolerance, and synthetically useful yields are some highlighted benefits of this process.
Topics & Concepts
SulfurCatalysisChemistryComponent (thermodynamics)Combinatorial chemistryMoleculeOrganic chemistryFunctional groupElemental analysisPolymerThermodynamicsPhysicsSynthesis and biological activitySulfur-Based Synthesis TechniquesSynthesis of heterocyclic compounds