Quantitative interrogation of protein co-aggregation using multi-color fluorogenic protein aggregation sensors
Yulong Bai, Wang Wan, Yanan Huang, Wenhan Jin, Haochen Lyu, Qiuxuan Xia, Xuepeng Dong, Zhenming Gao, Yu Liu
Abstract
. We also examined how small molecule ligands selectively and differentially interfere with such interplay. Finally, we demonstrated these sensors are suited to visualize how different proteins exert influence on each other upon their co-aggregation in live cells.
Topics & Concepts
Protein aggregationFluorescenceChemistryBiophysicsMutantProtein–protein interactionBiochemistryBiologyQuantum mechanicsPhysicsGeneCellular transport and secretionBiotin and Related StudiesLipid Membrane Structure and Behavior