Disruption of CISH promotes the antitumor activity of human T cells and decreases PD-1 expression levels
Jiang Lv, Le Qin, Ruocong Zhao, Di Wu, Zhiping Wu, Diwei Zheng, Siyu Li, Mintao Luo, Qiting Wu, Youguo Long, Zhaoyang Tang, Yan‐Lai Tang, Xue‐Qun Luo, Yao Yao, Li-Hua Yang, Peng Li
Abstract
. The level of FBXO38, a ubiquitination-regulating protein that reduces PD-1 expression, was elevated in activated T cells after CISH ablation. Hence, this study reveals a mechanism by which CISH promotes PD-1 expression by suppressing the expression of FBXO38 and proposes a new strategy for augmenting the therapeutic effect of CAR-T cells by inhibiting CISH.
Topics & Concepts
CISHCytokineCancer researchImmune systemT cellChimeric antigen receptorCell biologyBiologyChemistryImmunologyBiochemistryGene expressionGeneIn situ hybridizationCAR-T cell therapy researchImmune Cell Function and InteractionCancer Immunotherapy and Biomarkers