The Role of Lysine Methyltransferase SET7/9 in Proliferation and Cell Stress Response
Alexandra Daks, Elena Vasileva, Olga Fedorova, Oleg Shuvalov, Nickolai A. Barlev
Abstract
Lysine-specific methyltransferase 7 (KMT7) SET7/9, aka Set7, Set9, or SetD7, or KMT5 was discovered 20 years ago, yet its biological role remains rather enigmatic. In this review, we analyze the particularities of SET7/9 enzymatic activity and substrate specificity with respect to its biological importance, mostly focusing on its two well-characterized biological functions: cellular proliferation and stress response.
Topics & Concepts
MethyltransferaseCell growthLysineBiologyEnzymeCell biologyChemistryBiochemistryMethylationAmino acidDNAEpigenetics and DNA MethylationCancer-related gene regulationRNA modifications and cancer