The translational repressor 4E-BP1 regulates RRM2 levels and functions as a tumor suppressor in Ewing sarcoma tumors
Kelli L. Goss, Stacia L. Koppenhafer, Torin Waters, William W. Terry, Kuo-Kuang Wen, Meng Wu, Jason Ostergaard, Peter M. Gordon, David J. Gordon
Topics & Concepts
BiologyRibonucleotide reductaseProtein subunitDNA replicationmTORC1Protein biosynthesisE2FEIF4ETranslation (biology)Cell biologyCancer researchCell cycleMolecular biologyPI3K/AKT/mTOR pathwayDNABiochemistryCellGeneSignal transductionMessenger RNAProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysRNA modifications and cancer