Litcius/Paper detail

Cell-Free DNA: Hope and Potential Application in Cancer

Yanyan Yan, Qiaoru Guo, Fenghua Wang, Rameshwar Adhikari, Zhuang-yan Zhu, Haiyan Zhang, Wenmin Zhou, Hua Yu, Jingquan Li, Jianye Zhang

2021Frontiers in Cell and Developmental Biology138 citationsDOIOpen Access PDF

Abstract

Cell-free DNA (cfDNA) is easily accessible in peripheral blood and can be used as biomarkers for cancer diagnostics, prognostics, and therapeutics. The applications of cfDNA in various areas of cancer management are attracting attention. In this review article, we discuss the potential relevance of using cfDNA analysis in clinical oncology, particularly in cancer screening, early diagnosis, therapeutic evaluation, monitoring disease progression; and determining disease prognosis.

Topics & Concepts

Cell-free fetal DNAPrognosticsMedicineDiseaseCancerOncologyBioinformaticsInternal medicineBiologyComputer scienceGeneticsPregnancyPrenatal diagnosisData miningFetusCancer Genomics and DiagnosticsPancreatic and Hepatic Oncology ResearchRenal cell carcinoma treatment