Design, Synthesis, and Biological Evaluation of Novel 7<i>H</i>-[1,2,4]Triazolo[3,4-<i>b</i>][1,3,4]thiadiazine Inhibitors as Antitumor Agents
Muhammad I. Ismail, Samy Mohamady, Nermin Samir, Khaled A. M. Abouzid
Abstract
can be utilized as a starting scaffold for developing potential GSK-3β inhibitors.
Topics & Concepts
ChemistryGSK-3AnnexinKinaseDocking (animal)IsothiocyanateApoptosisIC50Cell cycle checkpointCancer cellBinding siteCell cycleStereochemistryBiochemistryIn vitroBiologyCancerMedicineGeneticsNursingSynthesis and Characterization of Heterocyclic CompoundsQuinazolinone synthesis and applicationsSynthesis and biological activity