Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses
Jay K. Mandula, Shiun Chang, Eslam Mohamed, Rachel Jimenez, Rosa A. Sierra-Mondragon, Darwin Chang, Alyssa Obermayer, Carlos Moran Segura, Satyajit Das, Julio Angel Vázquez-Martínez, Karol Prieto, Ann Chen, Keiran S.M. Smalley, Brian J. Czerniecki, Peter Forsyth, Richard C. Koya, Brian Ruffell, Juan R. Cubillos‐Ruiz, David H. Munn, Timothy I. Shaw, José R. Conejo-García, Paulo C. Rodrı́guez
Topics & Concepts
Unfolded protein responseEndoplasmic reticulumProtein kinase REIF-2 kinaseImmunogenic cell deathCancer researchProtein kinase AProgrammed cell deathCancer cellBiologyCancerApoptosisKinaseMedicineCell biologyInternal medicineMitogen-activated protein kinase kinaseCyclin-dependent kinase 2BiochemistryEndoplasmic Reticulum Stress and DiseasePhagocytosis and Immune RegulationAutophagy in Disease and Therapy