Addition of Carboxylic Acids to <i>gem</i>-Difluoroalkenes for the Synthesis of <i>gem</i>-Difluoromethylenated Compounds

Abstract

High Resolution Image Download MS PowerPoint Slide We herein describe a straightforward protocol for the synthesis of carboxylic esters containing a gem -difluoromethylene unit. Readily available carboxylic acids can act as nucleophiles to add regioselectively to tetrasubstituted or trisubstituted β,β-difluoroacrylates (formal hydroacetoxylation) for the construction of RCO 2 –CF 2 bonds. Thermal conditions are sufficient without the use of catalysts or additives.

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