Dexmedetomidine mitigates neuroinflammation and improves early postoperative neurocognitive dysfunction in rats by enhancing autophagy
Jinxu Wang, Yueyang Xin, Tiantian Chu, Ya‐Qun Zhou, Cheng Liu, Aijun Xu
Abstract
Dex inhibits hippocampal neuroinflammation and attenuates early cognitive impairment by enhancing autophagy following surgery in rats. Dex may protect postoperative cognitive function by activating the LKB1/AMPK/ULK-1 signaling pathway.
Topics & Concepts
AutophagyNeuroinflammationProinflammatory cytokineHippocampusPostoperative cognitive dysfunctionHippocampal formationNeuroprotectionWestern blotAMPKMedicineInternal medicineEndocrinologyPharmacologyChemistryInflammationCell biologyNeuroscienceBiologyProtein kinase APhosphorylationApoptosisBiochemistryCognitionGeneIntensive Care Unit Cognitive DisordersAnesthesia and Neurotoxicity ResearchNeuroinflammation and Neurodegeneration Mechanisms