Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis
Ehab Ghazy, Tino Heimburg, Julien Lancelot, Patrik Zeyen, Karin Schmidtkunz, Anne Truhn, Salma Darwish, Conrad V. Simoben, T.B. Shaik, Frank Erdmann, Matthias Schmidt, Dina Robaa, Christophe Romier, Manfred Jung, Raymond J. Pierce, Wolfgang Sippl
Topics & Concepts
ChemistryPraziquantelDocking (animal)SchistosomiasisSchistosoma mansoniIn vitroStructure–activity relationshipHistone deacetylaseHistone deacetylase inhibitorStereochemistryPharmacologyBiochemistryHistoneBiologyImmunologyHelminthsMedicineNursingGeneParasites and Host InteractionsHistone Deacetylase Inhibitors ResearchCholinesterase and Neurodegenerative Diseases