Glucocorticoid-Induced Ocular Hypertension and Glaucoma
Devon H. Harvey, Chenna Kesavulu Sugali, Weiming Mao
Abstract
Abstract: Glucocorticoid (GC) therapy is indicated in many diseases, including ocular diseases. An important side-effect of GC therapy is GC-induced ocular hypertension (GIOHT), which may cause irreversible blindness known as GC-induced glaucoma (GIG). Here, we reviewed the pathological changes that contribute to GIOHT including in the trabecular meshwork and Schlemm’s canal at cellular and molecular levels. We also discussed the clinical aspects of GIOHT/GIG including disease prevalence, risk factors, the type of GCs, the route of GC administration, and management strategies. Keywords: glucocorticoid, intraocular pressure, trabecular meshwork, aqueous humor outflow, mechanism, treatment
Topics & Concepts
MedicineTrabecular meshworkGlaucomaOcular hypertensionGlucocorticoidBlindnessOphthalmologyPathologicalSchlemm's canalDiseaseBioinformaticsOptometryPathologyInternal medicineBiologyGlaucoma and retinal disordersOphthalmology and Eye DisordersOcular Oncology and Treatments