Pseudomonas aeruginosa Phosphate Transporter PitA (PA4292) Controls Susceptibility to Aminoglycoside Antibiotics by Regulating the Proton Motive Force
Xinrui Zhao, Yongxin Jin, Fang Bai, Zhihui Cheng, Weihui Wu, Xiaolei Pan
Abstract
mutant restores the intracellular phosphate concentration, PMF, ATP synthesis, and aminoglycosides resistance. In addition, growth of wild-type PA14 in a low-phosphate medium resulted in higher PMF and aminoglycoside susceptibility compared to cells grown in a high-phosphate medium. Overall, our results demonstrate the roles of PitA in phosphate transportation and reveal the relationship between intracellular phosphate and aminoglycoside susceptibility.
Topics & Concepts
AminoglycosidePseudomonas aeruginosaMutantTobramycinMicrobiologyIntracellularEscherichia coliAntibioticsBiologyChemistryBacteriaBiochemistryGeneGentamicinGeneticsAntibiotic Resistance in BacteriaBacterial Genetics and BiotechnologyDrug Transport and Resistance Mechanisms