Indazole and its Derivatives in Cardiovascular Diseases: Overview,Current Scenario, and Future Perspectives
Shravan Kumar Uppulapu, Md Jahangir Alam, Santosh Kumar, S. K. Banerjee
Abstract
Indazoles are a class of heterocyclic compounds with a bicyclic ring structure composed of a pyrazole ring and a benzene ring. Indazole-containing compounds with various functional groups have important pharmacological activities and can be used as structural motifs in designing novel drug molecules. Some of the indazole-containing molecules are approved by FDA and are already in the market. However, very few drugs with indazole rings have been developed against cardiovascular diseases. This review aims to summarize the structural and pharmacological functions of indazole derivatives which have shown efficacy against cardiovascular pathologies in experimental settings.
Topics & Concepts
IndazoleRing (chemistry)PyrazoleChemistryCombinatorial chemistryDrug discoveryMoleculePharmacologyComputational biologyStereochemistryMedicineBiologyOrganic chemistryBiochemistrySynthesis and biological activityComputational Drug Discovery MethodsNuclear Receptors and Signaling