Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing
Joseph M. Replogle, Thomas M. Norman, Albert Xu, Jeffrey A. Hussmann, Jin Chen, J. Zachery Cogan, Elliott J. Meer, Jessica M. Terry, Daniel P. Riordan, Niranjan Srinivas, Ian T. Fiddes, Joseph G. Arthur, Luigi J. Alvarado, Katherine A. Pfeiffer, Tarjei S. Mikkelsen, Jonathan S. Weissman, Britt Adamson
Topics & Concepts
CRISPRCRISPR interferenceSubgenomic mRNAGuide RNAComputational biologyBiologyCas9Trans-activating crRNASingle-cell analysisGeneticsGenome editingBiogenesisRNAGeneCellCRISPR and Genetic EngineeringSingle-cell and spatial transcriptomicsRNA and protein synthesis mechanisms