Interruption of p38<sup>MAPK</sup>-MSK1-CREB-MITF-M pathway to prevent hyperpigmentation in the skin
Song-Hee Kim, Jiyeon Lee, Ji‐Hye Jung, Ga Hyun Kim, Cheong‐Yong Yun, Sang‐Hun Jung, Bang Yeon Hwang, Jin Tae Hong, Sang‐Bae Han, Jae‐Kyung Jung, Young Soo Kim
Abstract
-MSK1-CREB-MITF-M pathway was suggested as a rationale to inhibit UV-B- or α-MSH-induced facultative melanogenesis and as a strategy to prevent acquired pigmentary disorders in the skin.
Topics & Concepts
Microphthalmia-associated transcription factorMelanocortin 1 receptorCREBMelanocyteTyrosinaseMelaninMelanocyte-stimulating hormoneProtein kinase ABiologyReceptorTranscription factorHairlessMAPK/ERK pathwayTLR4Molecular biologyCell biologySignal transductionEndocrinologyKinaseChemistryCancer researchBiochemistryMelanomaGenePhenotypeEnzymemelanin and skin pigmentationSkin Protection and AgingBiochemical Analysis and Sensing Techniques