Myocardial and Pericardial Toxicity Associated With Immune Checkpoint Inhibitors in Cancer Patients
Johnny Chahine, Patrick Collier, Anjli Maroo, W.H. Wilson Tang, Allan L. Klein
Abstract
We recount a single-center experience with cardiac immunity-related adverse effects in patients treated with immune checkpoint inhibitors. Of 2,830 patients, 9 patients (0.3%) developed cardiac immunity-related adverse effects (4 cases of cardiomyopathies, 2 of myocarditis, 2 of acute pericarditis, and 1 of large pericardial effusion). Disease profiles, hospital courses, and outcomes are reported. (Level of Difficulty: Advanced.)
Topics & Concepts
MedicinePericardial effusionAdverse effectMyocarditisPericarditisCardiotoxicityInternal medicineCardiologyImmunityAcute pericarditisDiseaseImmune systemToxicityImmunologyCancer Immunotherapy and BiomarkersPericarditis and Cardiac TamponadeChemotherapy-induced cardiotoxicity and mitigation