Roles of Mitochondria in Oral Squamous Cell Carcinoma Therapy: Friend or Foe?
Junqiang Bai, Luping Wu, Xinmiao Wang, Yifan Wang, Zhengjun Shang, Erhui Jiang, Zhe Shao
Abstract
Oral squamous cell carcinoma (OSCC) therapy is unsatisfactory, and the prevalence of the disease is increasing. The role of mitochondria in OSCC therapy has recently attracted increasing attention, however, many mechanisms remain unclear. Therefore, we elaborate upon relative studies in this review to achieve a better therapeutic effect of OSCC treatment in the future. Interestingly, we found that mitochondria not only contribute to OSCC therapy but also promote resistance, and targeting the mitochondria of OSCC via nanoparticles is a promising way to treat OSCC.
Topics & Concepts
Basal cellMitochondrionCancer researchCellDiseaseMedicineBiologyPathologyCell biologyBiochemistryMitochondrial Function and PathologyCancer, Hypoxia, and MetabolismNanoplatforms for cancer theranostics