Contribution of Host miRNA-223-3p to SARS-CoV-Induced Lung Inflammatory Pathology
Lucía Morales, Juan Carlos Oliveros, Luis Enjuanes, Isabel Sola
Abstract
The SARS-CoV-2 pandemic has emphasized the need to understand the mechanisms of severe lung inflammatory pathology caused by human deadly coronaviruses in order to design new antiviral therapies. Here, we identify miRNA-223-3p as a host miRNA involved in the regulation of lung inflammatory response mediated by envelope (E) protein during SARS-CoV infection. miRNAs downregulate the expression of cellular mRNAs and participate in complex networks of mRNA–miRNA interactions that regulate cellular processes.
Topics & Concepts
InflammationVirulenceImmunologyLungCoronavirusBiologyInflammasomemicroRNAProinflammatory cytokineGene silencingVirologyMedicineDiseasePathologyCoronavirus disease 2019 (COVID-19)GeneInfectious disease (medical specialty)BiochemistryInternal medicineMicroRNA in disease regulationExtracellular vesicles in diseaseinterferon and immune responses