Hypoxia Inducible Factor-1α binds and activates γ-secretase for Aβ production under hypoxia and cerebral hypoperfusion
Courtney Alexander, Thomas Li, Yorito Hattori, Danica Chiu, Georgia Frost, Lauren A. Jonas, Chenge Liu, Corey J. Anderson, Eitan Wong, Laibaik Park, Costantino Iadecola, Yue‐Ming Li
Topics & Concepts
Hypoxia (environmental)Amyloid precursor protein secretaseDownregulation and upregulationProteasesHypoxia-inducible factorsNeuroscienceCell biologyChemistryBiologyPharmacologyMedicineCancer researchAmyloid precursor proteinAlzheimer's diseaseInternal medicineDiseaseBiochemistryEnzymeGeneOrganic chemistryOxygenAlzheimer's disease research and treatmentsEpigenetics and DNA MethylationAutophagy in Disease and Therapy