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Blocking STAT3 by pyrvinium pamoate causes metabolic lethality in KRAS-mutant lung cancer

Juanjuan Feng, Wenhao Jiang, Yanan Liu, Wanfeng Huang, Kewen Hu, Kun Li, Jing Chen, Chengbin Ma, Zhenliang Sun, Xiufeng Pang

2020Biochemical Pharmacology23 citationsDOI

Topics & Concepts

STAT3KRASCancer researchIn vivoLung cancerSynthetic lethalityCancer cellCancerMedicinePharmacologyMutantBiologySignal transductionCell biologyInternal medicineBiochemistryColorectal cancerBiotechnologyGeneCytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatasesinterferon and immune responses
Blocking STAT3 by pyrvinium pamoate causes metabolic lethality in KRAS-mutant lung cancer | Litcius