Derivatization based on tetrazine scaffolds: synthesis of tetrazine derivatives and their biomedical applications
Hongbao Sun, Qinghe Xue, Chang Zhang, Haoxing Wu, Ping Feng
Abstract
The recent advances in tetrazine scaffold-based derivatizations have been summarized. The advantages and limitations of derivatization methods and applications of the developed tetrazine derivatives in bioorthogonal chemistry have been highlighted.
Topics & Concepts
TetrazineChemistryDerivatizationCombinatorial chemistryOrganic chemistryHigh-performance liquid chromatographyClick Chemistry and ApplicationsChemical Synthesis and AnalysisSynthesis and Biological Evaluation