Peptides to Overcome the Limitations of Current Anticancer and Antimicrobial Nanotherapies
Valentina Del Genio, Rosa Bellavita, Annarita Falanga, Katel Hervé-Aubert, Igor Chourpa, Stefania Galdiero
Abstract
Biomedical research devotes a huge effort to the development of efficient non-viral nanovectors (NV) to improve the effectiveness of standard therapies. NVs should be stable, sustainable and biocompatible and enable controlled and targeted delivery of drugs. With the aim to foster the advancements of such devices, this review reports some recent results applicable to treat two types of pathologies, cancer and microbial infections, aiming to provide guidance in the overall design of personalized nanomedicines and highlight the key role played by peptides in this field. Additionally, future challenges and potential perspectives are illustrated, in the hope of accelerating the translational advances of nanomedicine.