Characterization of Functional B-Cell Epitopes at the Amino Terminus of <i>Shigella</i> Invasion Plasmid Antigen B (IpaB)
Siqi Li, Xinfeng Han, Ipshita Upadhyay, Weiping Zhang
Abstract
Currently, there are no effective measures for control or prevention of Shigella infection, the most common cause of diarrhea in children 3 to 5 years of age in developing countries. Challenges in developing Shigella vaccines include virulence heterogeneity among species and serotypes.
Topics & Concepts
ShigellaMicrobiologyVirulenceSerotypeBiologyEpitopePlasmidDiarrheaShigella flexneriAntigenVirologyVirulence factorBacteriaImmunologySalmonellaEscherichia coliMedicineGeneticsGeneInternal medicineEscherichia coli research studiesViral gastroenteritis research and epidemiologyvaccines and immunoinformatics approaches