ACE2 activator diminazene aceturate ameliorates Alzheimer's disease-like neuropathology and rescues cognitive impairment in SAMP8 mice
Rui Duan, Xue Xiao, Qiao-Quan Zhang, Siyu Wang, Pengyu Gong, Yan E, Teng Jiang, Yingdong Zhang
Abstract
, hyperphosphorylated tau and pro-inflammatory cytokines in the brain. The synaptic and neuronal losses in the brain were ameliorated by DIZE. Importantly, DIZE improved spatial cognitive functions in the Morris water maze test. In conclusion, this study demonstrates that DIZE ameliorates AD-like neuropathology and rescues cognitive impairment in SAMP8 mice. These beneficial effects of DIZE may be achieved by activating brain ACE2/Ang-(1-7)/MAS1 axis. These findings highlight brain ACE2/Ang-(1-7)/MAS1 axis as a potential target for the treatment of sporadic AD.
Topics & Concepts
NeuropathologyCognitive impairmentActivator (genetics)NeuroscienceAlzheimer's diseaseMedicineDiseaseCognitionPharmacologyPsychologyInternal medicineReceptorRenin-Angiotensin System StudiesComputational Drug Discovery MethodsHormonal Regulation and Hypertension