Hybrid pharmacophore design and synthesis of donepezil-inspired aurone derivative salts as multifunctional acetylcholinesterase inhibitors
Rei Funahashi, Fumiaki Matsuura, Masayuki Ninomiya, Sayo Okabe, Shigeo Takashima, Kaori Tanaka, Atsuyoshi Nishina, Mamoru Koketsu
Topics & Concepts
ChemistryDonepezilAcetylcholinesterasePharmacophoreNeuriteDerivative (finance)PharmacologyIn vitroAchéFlavonoidDrugAcetylcholinesterase inhibitorCytotoxicityCombinatorial chemistryBiochemistryDementiaEnzymeDiseaseAntioxidantInternal medicineFinancial economicsEconomicsMedicineSynthesis of Organic CompoundsSynthesis and biological activityCholinesterase and Neurodegenerative Diseases