Analysis of the Risk Factors for Mortality in Adult COVID-19 Patients in Wuhan: A Multicenter Study
Man Li, Biao Cheng, Wen Zeng, Sichao Chen, Mengqi Tu, Meng Wu, Wei Tong, Shipei Wang, Yihui Huang, Wei Long, Wei Zhou, Danyang Chen, Lin Zhou, Min Wang, Haibo Xu, Aiping Deng, Zeming Liu, Liang Guo
Abstract
Objectives: An outbreak of coronavirus disease (COVID-19) in 2019 in Wuhan, China, has spread quickly worldwide. However, the risk factors associated with COVID-19-related mortality remain controversial. Methods: 245 adult patients with laboratory-confirmed COVID-19 from two centers were analyzed. Chi-square test, Fisher’s exact test and the Mann-Whitney U test were used to compare the clinical characteristics between the survivors and non-survivors. To explore the risk factors associated with in-hospital death, univariable and multivariable cox regression analyses were used. Results: Of the 245 patients included in this study, 23 (9.4%) died in the hospital. The multivariate regression analysis showed increased odds of in-hospital deaths associated with age, D-dimer levels >1000 ng/L, platelet count < 125, and higher serum creatinine levels. Conclusions: We identified risk factors that show significant association with mortality in adult COVID-19 patients, and our findings provide valuable references for clinicians to identify high-risk patients with COVID-19 at an early stage.