Can SARS-CoV-2 Accumulate Mutations in the S-Protein to Increase Pathogenicity?
Aditya K. Padhi, Timir Tripathi
Abstract
SARS-CoV-2 has developed a substantial number of mutations, especially in the S-protein. With the advancement of the pandemic, accumulations of further mutations at the S-protein receptor-binding domain could enhance the infectivity and pathogenicity of the virus. Prediction and evaluation of such mutations are essential for understanding the potential development of more pathogenic strains and for COVID-19 management.
Topics & Concepts
PathogenicityInfectivityMutationBiologyVirologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)VirusPandemicCoronavirus disease 2019 (COVID-19)Spike ProteinCoronavirusGeneticsGeneMicrobiologyMedicineInfectious disease (medical specialty)DiseasePathologySARS-CoV-2 and COVID-19 Researchvaccines and immunoinformatics approachesComputational Drug Discovery Methods