Temperature controlled condensation of nitriles: efficient and convenient synthesis of β-enaminonitriles, 4-aminopyrimidines and 4-amidinopyrimidines in one system
Yinghua Li, Yingzu Zhu, Shiqun Xiang, Weibin Fan, Jin Jiang, Deguang Huang
Abstract
A wide variety of β-enaminonitriles, 4-aminopyrimidines and 4-amidinopyrimidines were simply synthesized from organonitriles by controlling the reaction temperature.
Topics & Concepts
Steric effectsChemistryCondensationStoichiometryIntermolecular forceTransformation (genetics)Condensation reactionCombinatorial chemistryScope (computer science)Computational chemistryOrganic chemistryMoleculeComputer scienceThermodynamicsCatalysisGeneBiochemistryPhysicsProgramming languageSynthesis and Catalytic ReactionsMulticomponent Synthesis of HeterocyclesSynthesis of heterocyclic compounds