METTL14 regulates chromatin bivalent domains in mouse embryonic stem cells
Mandi Mu, Xinze Li, Dong Li, Jin Wang, Qingqing Cai, Jun Hu, Duanduan Wang, Peng Zhao, Lei Zhang, Daixuan Zhang, Siyi Cheng, Li Xuan Tan, Feizhen Wu, Yujiang Geno Shi, Wenqi Xu, Yang Shi, Hongjie Shen, Yang Shi, Hongjie Shen
Abstract
(Cell Reports 42, 112650; June 27, 2023) In the originally published version of this article, Figure 4 was erroneously duplicated in the supplemental information as Figure S4 during our last submission. The mistake has been corrected in the online version of the article. The authors regret this error. METTL14 regulates chromatin bivalent domains in mouse embryonic stem cellsMu et al.Cell ReportsJune 13, 2023In BriefMu et al. show that METTL14 mainly localizes to bivalent domains in mouse embryonic stem cells and regulates bivalency independent of its partner METTL3 or m6A modification. Mettl14 loss results in decreased H3K27me3 but increased H3K4me3 levels at bivalent domains, possibly through regulation of recruitment of PRC2 and KDM5B. Full-Text PDF Open Access